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首页> 外文OA文献 >A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities
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A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities

机译：一种新的黄柏和黄柏叶中的类黄酮C-糖苷及其潜在的抗氧化和细胞毒活性

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A major development over the past two decades has been the realization that free radical induced lipid peroxidation and DNA damage are associated with major health problems, e.g. cancer and ageing. Plant-derived antioxidants are increasingly found beneficial in protecting against these diseases. Celtis australis L. and Celtis occidentalis L. are two plants that have a variety of uses in folk medicine but have not been evaluated before for their antioxidant and cytotoxic properties. Therefore, the extracts of both plants’ leaves were investigated for these activities, as well as isolation of the bioactive compounds responsible for the activities. Molecular structures of the compounds were elucidated by UV, HRESIMS, 1D (1H and 13C) and 2D (1H-13C HSQC and 1H-13C HMBC) NMR analyses. The ethanolic and aqueous extracts, n-butanol fractions and the isolated major compound were tested for their antioxidant activity using DPPH radical scavenging assay, xanthine oxidase-induced generation of superoxide radical and lipid peroxidation assay by thiobarbituric acid-reactive substances (TBARS) method using rat tissue homogenates. Cytotoxic activities were studied using standard MTT assay. A novel flavonoid C-triglycoside, 4‴-α-rhamnopyranosyl-2″-O-β-d-galactopyranosylvitexin, was isolated from both plants’ leaves, together with seven known flavonoids. The n-butanol fractions and the major compound 2″-O-β-galactopyranosylvitexin showed significant antioxidant activities, more pronounced than the tested standards BHT and dl-α-tocopherol in most tests. All extracts showed variable cytotoxic activities. This study provides strong evidence for the antioxidant and cytotoxic activities of the extracts of Celtis australis L. and Celtis occidentalis L. leaves, which were attributed to the polar n-butanol fractions and the major isolated flavonoid 2″-galactosylvitexin.
机译：过去二十年来的主要发展是认识到自由基诱导的脂质过氧化和DNA损伤与主要的健康问题有关，例如糖尿病。癌症和衰老。越来越多地发现植物来源的抗氧化剂可有效预防这些疾病。南方Celtis L.和西方Celtis occidentalis是两种植物，在民间医学中具有多种用途，但之前尚未经过抗氧化剂和细胞毒性特性的评估。因此，研究了两种植物叶子的提取物的这些活性，以及​​分离出负责这些活性的生物活性化合物。通过UV，HRESIMS，1D（1H和13C）和2D（1H-13C HSQC和1H-13C HMBC）NMR分析阐明了化合物的分子结构。使用DPPH自由基清除测定，黄嘌呤氧化酶诱导的超氧化物自由基生成和脂质过氧化测定（使用硫代巴比妥酸反应性物质（TBARS）方法）测试了乙醇和水提取物，正丁醇馏分和分离出的主要化合物的抗氧化活性。大鼠组织匀浆。使用标准MTT测定法研究细胞毒性活性。从两株植物的叶子中分离出一种新颖的类黄酮C-三糖苷4‴-α-鼠李糖基吡喃糖基-2”-O-β-d-吡喃半乳糖基维生素，以及7种已知的类黄酮。正丁醇馏分和主要化合物2''-O-β-吡喃半乳糖基维生素显示出显着的抗氧化活性，在大多数测试中比被测标准BHT和dl-α-生育酚更显着。所有提取物均显示出不同的细胞毒活性。这项研究提供了强有力的证据，证明了澳大利亚Celtis australis L.和Celtis occidentalis L.叶提取物的抗氧化和细胞毒性活性，这归因于极性正丁醇级分和主要的分离的类黄酮2”-半乳糖基维他命。

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